5-HT₂ Receptor Agonist

25N-N1-Nap is a blood-brain barrier-permeable, selective, β-arrestin2-biased 5-HT_2A receptor (5-HT_2AR) agonist. 25N-N1-Nap reduces Gq efficacy while preserving β-arrestin2 efficacy. 25N-N1-Nap does not induce hallucinogen-like behavioral responses, blocks hyperactivity induced by hallucinogens and psychostimulants, and induces rapid tolerance to hallucinogen-like responses. 25N-N1-Nap can be used for research on schizophrenia-related hyperactivity.

5-HT2A receptor agonist-2 is a highly potent serotonin 5-HT2 receptor agonists. 5-HT2A receptor agonist-2 inspires 5-HT_2A, 5-HT_2B, and 5-HT_2C with EC₅₀ values of 1.7, 0.58, and 0.50 nM, respectively.

VU6067416 is a potent and brain-penetrant 5-HT2A agonist with an EC₅₀ of 189 nM.

PF-04781340 is a potent and selective 5-HT₂C receptor agonist, with an EC₅₀ of 9 nM and a K_i of 3 nM, respectively. PF-04781340 exhibits weak partial agonist activity at the 5-HT₂B receptor, with an EC₅₀ of 1484 nM. PF-04781340 can be used in the research of obesity and psychiatric disorders.

5-HT2A receptor agonist-9 (Compound 9) is a β-arrestin-biased 5-HT_2A receptor agonist. 5-HT2A receptor agonist-9 can be used in the research of neurological diseases such as antidepressant and psychedelic.

5-HT2A agonist 7 (Compound 45) is an orally active and highly selective serotonin receptor 2A (5-HT_2A) agonist (EC₅₀=12 nM). 5-HT2A agonist 7 is promising for research of psychiatric disorders such as depression.

2C-TFM hydrochloride is a ,5-dimethoxyphenethylamines compound with a para-trifluoromethyl substitution. 2C-TFM hydrochloride is a potent agonist of the 5-HT receptor subtypes 5-HT2A and 5-HT2C.

IHCH-8110 is a peripherally restricted, non-brain-penetrant 5-HT_2AR and 5-HT_2CR agonist (K_i=47.86 nM) that antagonizes 5-HT_2BR. IHCH-8110 induces CXCL10 and IL-18 expression by activating 5-HT_2AR on enteric glial cells, thereby promoting CD8⁺ T cell recruitment and effector polarization, and avoids the risk of cardiac valvulopathy associated with 5-HT_2BR activation. IHCH-8110 exhibits a low risk of hERG channel inhibition (IC₅₀=5.96 μM) and is well tolerated, sensitizing immunologically cold colorectal cancer to PD-1 blockade therapy, making it suitable for research related to colorectal cancer.

5-HT2A agonist-11 (Compound S82) is a 5-HT2A receptor agonist with an EC₅₀ of 1.5 nM. 5-HT2A agonist-11 can be used for the research of central nervous system diseases.

5-HT2C agonist-5 (Compound 3A) is a 5-HT2C agonist (EC₅₀: <1 nM). 5-HT2C agonist-5 can be used for research of brain disorders.

PF-4479745 is a potent and selective 5-HT_2C receptor agonist (EC₅₀: 10 nM, k_i: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension.

5-HT2A agonist 3 (Compound P-141) is a selective 5-hydroxytryptamine 2A receptor (5-HT_2A) agonist with an EC₅₀ value of 13.80 nM. 5-HT2A agonist 3 is promising for research of mental illnesses such as depression, post-traumatic stress disorder, obsessive-compulsive disorder, and central nervous system disorders.

4-Hydroxy MPT (4-OH-MPT), a serotonergic hallucinogen, is a 5-HT2A and 5-HT2B receptors agonist with EC₅₀ values of 3.82 nM and 3.4 nM, respectively.

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT_2C receptor agonist and exhibits pEC₅₀ values of 7.01, 6.38 and 6.28 for 5-HT_2C, 5-HT_2A and 5-HT_2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.

WAY 629 is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 decreases feeding behavior.

WAY 208466 is a selective 5-HT6 receptor agonist with an EC₅₀ of 7.3 nM. WAY-208466 increases GABA levels following both acute and chronic administration in the dorsolateral frontal cortex of rat models with stereotaxic surgery. WAY 208466 can be used for anxiety-related disorders like obsessive compulsive disorder (OCD) research.

5-HT2A agonist 6 (compound 2-6) is a 5-HT2A agonist with an EC₅₀ of 1.7 nM. 5-HT2A agonist 6 is used in the study of stress-related disorders, namely depression, anxiety, and post-traumatic stress disorder.

5-HT2A agonist-12 is a human 5-HT2A receptor agonist with an EC₅₀ of 0.78 μM (in Chinese hamster ovary cells). 5-HT2A agonist-12 modulates intracellular calcium mobilization in cells expressing the human 5-HT2A receptor. 5-HT2A agonist-12 can be used in research related to depression.

5-HT2 agonist-1 (Compound 24) free base is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC₅₀s of 10 nM, 8.3, and 1.6 nM respectively. 5-HT2 agonist-1 free base can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders.

5-HT2C agonist-13 is an orally active, selective and brain-penetrant 5-HT_2C receptor agonist with human 5-HT_2C receptor EC₅₀ of 16 nM, K_i of 20 nM. 5-HT2C agonist-13 functionally activates 5-HT_2C receptors, reduces food intake, reduces body weight gain, and exhibits effects reversible by a selective 5-HT_2C antagonist. 5-HT2C agonist-13 can be used for the research of obesity.